“Biohacking” our genes using Celsus One and Nrf2 Activation

In my practice, I am a “biohacker”, helping my patients become healthy at the cellular level,
using biomarkers, saliva tests, bloodwork, and new-age supplements; hacking the genetic code
to help my patients live a preventive lifestyle. I often tell my patients that their mouth is an
indication of their internal body tissue health. Incorporating the genetic analysis report from the
Celsus One test helps me establish personalized health recommendations utilizing genetic risk
factors and biomarkers related to the oral and systemic inflammatory response.

Utilizing genetics with products that activate NRF1(Nuclear respiratory factor1) and Nrf2
(nuclear factor erythroid 2 (NFE2)-related factor 2) pathways to create internal cellular
molecules can turn back the aging process and become part of a full preventive program.
Considering that there are over 200 disease processes that start with inflammation, it’s exciting
that the Celsus One shows 8 biomarkers associated with periodontal, diabetes, cardiovascular
and arthritis. The genotypes of each biomarker affect the inflammatory index and the second
page of the report supports my treatment recommendations.

Since the lab results are the patient’s own genetic makeup, dental health providers can educate
patients on how the genotypes of the biomarkers affect their long term systemic health. The
three innate; Beta-defensin 1 (DEFB1) CD14 (CD14), and Toll-like receptor 4 (TLR4), and five
acquired; Tumor necrosis factor-alpha (TNF-alpha) Interleukin 1 (IL1), Interleukin 6 (IL6)
Interleukin 17A (IL17A) Matrix Metallopeptidase 3 (MMP3) have different variations in degree of
severity in association with inflammatory disease processes. The variations for personalizing
patient care helps me to decide what tools, frequency, environmental challenges, and ultimately
how to best educate my patients in being proactive. My patients feel empowered knowing they
can make a difference and control their genetics via their environment.

One of my favorite product lines that I have incorporated and researched works at the cellular
level to activate ATP, Mitochondria, and has been clinically proven to reduce oxidative damage
by 40% within 30 days. Protandim, Nrf2 Activator, has 5 patents with over 25 independent peer
reviews found on Oxidative stress (free radical damage) is the root cause of all
disease processes and has been linked to many health conditions. Nrf2 is a protein that
regulates the expression of antioxidants proteins that protect against oxidative damage
triggered by injury and inflammation. The Nrf2 protein remains dormant within each cell of our
body, unable to move or perform its task until released by an Nrf2 activator.

The Nrf2 genetic pathway turns on over 400 transcription genes such as GSTP1 which is
related to detoxification. Prior to the Protandim product line, Sulforaphane, found in broccoli
sprouts, was the “gold” standard of naturally occurring Nrf2 activators. Studies have shown
that Protandim Nrf2 activator is 150 fold more powerful than Sulforaphane. Protandim Nrf2 is
composed of 5 herbs that each in their own right has an ayurvedic effect. However, together
have been proven to work synergistically better than each component by itself.

A second activator, Protandim NRF1, works as a “one-two Punch” increasing ATP, Mitochondrial
DNA transcription, replication activity, and quality of sleep.
Knowing what patients are at risk even before sign and symptoms occur, helping those that
understand this be more aggressive treatment and becoming proactive with patient care is
possible utilizing personalized genetics.
To find out more about this please go to the website or contact Dr. Kimberly Hubenette for

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